Association between polymorphisms in MDM2 gene and oral cancer risk: a meta-analysis

This study aims to to systematically summarize the association between the polymorphisms of human homolog of mouse double minute 2 (MDM2) gene and oral cancer susceptibility. The relevant articles were searched from PubMed and Embase database. Studies were selected according to inclusion criteria and exclusion criteria. Seven studies were included in this meta-analysis. Seven data sets including 2108 cases and 2999 controls were about rs2279744 polymorphism; 801 cases and 1167 controls in 3 data sets were for rs937283 polymorphism. For MDM2 rs2279744 polymorphism, the individuals carrying TT genotype were more likely to develop oral cancer compared to those with GT or GG genotype (recessive model TT vs. GT+GG: OR=1.27, 95% CI=1.01-1.60, P=0.012 for heterogeneity). There were no significant associations between rs937283 polymorphism and oral cancer in any genetic model. In the stratified analysis by ethnicity, the associations between rs2279744 and oral cancer were significant among Caucasian population under the homogeneity model (TT versus GG: OR=1.57, 95% CI=1.12-2.21), the recessive model (TT versus GT+GG: OR=1.61, 95% CI=1.33-1.95) and the allelic model (T versus G: OR=1.34, 95% CI=1.13-1.58). However, the result among Asians was not statistically significant. There were not significant results in the stratified analysis by tumor type. Rs2279744 in MDM2 gene might be associated with susceptibility of oral cancer.